Effective for treatment of persistent infection, selected problem wounds, necrosis and ischemic conditions, including:

• Chronic non-healing wounds, especially where hypoxia is present

• Wagner III and greater diabetic foot ulcers*

• Refractory osteomyelitis*

• Radiation necrosis of bone or soft tissue*

• Soft tissue infection with tissue necrosis due to anaerobic infections*

• Gas gangrene (clostridial myonecrosis)*

• Compromised skin grafts or fl aps*

• Acute traumatic ischemia/crush injury/compartment syndrome*

• Thermal burns

Other indications include:

• Acute carbon monoxide poisoning*

• Acute gas embolism*

• Decompression sickness*

• Acute cyanide poisoning*

• Severe blood loss anemia (when blood transfusion is impossible or delayed)

Breathing 100% oxygen at atmospheric pressures of up to three atmospheres raises the arterial PaO2 to more than 2,000mm Hg. This elevation leads to:

• Rapid dissociation of carbon monoxide from hemoglobin and central nervous

• system cytochrome enzymes

• Elimination of intravascular and tissue gas bubbles, and restoration of

• CNS perfusion in gas embolism

• Reversal of local tissue hypoxia

• Enhanced collagen production, fibroblast proliferation, and neovascularization to provide support for the growth of granulation tissue.

• Suppression of bacterial function and toxin production

• Enhanced leukocyte and macrophage function